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MBE Advance Access originally published online on August 28, 2008
Molecular Biology and Evolution 2008 25(11):2421-2430; doi:10.1093/molbev/msn190
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© The Author 2008. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Articles

Recurrent Positive Selection of the Drosophila Hybrid Incompatibility Gene Hmr

Shamoni Maheshwari, Jun Wang and Daniel A. Barbash

Department of Molecular Biology and Genetics, Cornell University

E-mail: dab87{at}cornell.edu.

Accepted for publication August 15, 2008.

Lethality in hybrids between Drosophila melanogaster and its sibling species Drosophila simulans is caused in part by the interaction of the genes Hybrid male rescue (Hmr) and Lethal hybrid rescue (Lhr). Hmr and Lhr have diverged under positive selection in the hybridizing species. Here we test whether positive selection of Hmr is confined only to D. melanogaster and D. simulans. We find that Hmr has continued to diverge under recurrent positive selection between the sibling species D. simulans and Drosophila mauritiana and along the lineage leading to the melanogaster subgroup species pair Drosophila yakuba and Drosophila santomea. Hmr encodes a member of the Myb/SANT-like domain in ADF1 (MADF) family of transcriptional regulators. We show that although MADF domains from other Drosophila proteins have predicted ionic properties consistent with DNA binding, the MADF domains encoded by different Hmr orthologs have divergent properties consistent with binding to either the DNA or the protein components of chromatin. Our results suggest that Hmr may be functionally diverged in multiple species.

Key Words: adaptive evolution • hybrid incompatibility • speciation • MADF domain • positive selection

Michael Nachman, Associate Editor


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